In 2008, Burton-Morgan appeared in both the Fox Searchlight Pictures drama The Secret Life of Bees, as the deceased mother of Dakota Fanning's character, and the limited release thriller The List. Burton-Morgan was next cast in the film Bloodworth opposite Hilary Duff and Val Kilmer, an adaptation of the novel Provinces of Night by William Gay. The film premiered after her exit from One Tree Hill, at the 2010 Santa Barbara International Film Festival, but made little money in limited release. Burton-Morgan won a recurring arc in the USA Network crime drama series White Collar in 2010 as Sara Ellis, an insurance investigator in the second season. She was upgraded to a series regular in 2011 for the third season, but switched back to the recurring cast in the fourth season. 2012 saw Burton-Morgan guest-starring on the ABC police comedy-drama Castle (season 4, episode 13) as a reality television star who is accused of murder. Next came a recurring role in the ABC medical drama Grey's Anatomy for the final three episodes of the 2013 ninth season, as Dr. Lauren Boswell. That fall, Burton-Morgan had a recurring role on the short-lived CBS drama Hostages. Burton-Morgan reunited with One Tree Hill co-star Tyler Hilton for a recurring role on CBS sci-fi drama Extant in 2015. Burton-Morgan appeared as the DEA agent love interest of main character Martin Riggs on Lethal Weapon from the seventh episode of the first season in 2016 through the third episode of the second season in 2017.