On September 13, 2015, Reed caught seven passes for 63 yards and his first touchdown of the season against the Miami Dolphins, a four-yarder. On October 25, 2015, Reed caught a career-high 11 passes for 72 yards and a career-high two touchdowns against the Tampa Bay Buccaneers. The touchdowns were from 3 and 6 yards out, respectively. On November 15, 2015, Reed caught two more touchdowns against the New Orleans Saints, a 16-yard reception and an 8-yard reception. On November 29, 2015, Reed caught 8 passes for 98 yards against the New York Giants. On December 13, 2015, Reed caught 9 passes for 120 yards and a touchdown against the Chicago Bears for his 3rd 100-plus yard game of his career. On December 20, 2015, Reed caught 7 passes for 84 yards against the Buffalo Bills. Reed caught two touchdowns for the 3rd time this season, one from 3 yards out, and the other from 18 yards out. On December 26, 2015, Reed recorded 129 yards off of nine receptions and two touchdowns against the Philadelphia Eagles to win the NFC East. In his first playoff game, Reed recorded nine passes for 120 yards and one touchdown against the Green Bay Packers. He was ranked 77th on the NFL Top 100 Players of 2016.